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Endocrine Disruptors, Genital Development and Hypospadias
A 2013 study states hypospadias is one of the most common congenital anomalies in the United States, occurring in approximately 1 in 125 live male births. With recent advancements in molecular biology and microarray technology, it appears that hypospadias is potentially related to disrupted gene expression. Specifically, some of the environmental chemicals are acting as antiandrogens and interfere directly with the action of testosterone-related gene expression.