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Mono-2-ethylhexyl Phthalate-Induced Downregulation of MMP11 in Foreskin Fibroblasts Contributes to the Pathogenesis of Hypospadias
A 2024 study states that hypospadias is one of the most common congenital anomalies of the male urogenital system, and di(2-ethylhexyl) phthalate (DEHP), a widely used endocrine-disrupting chemical (EDC), is considered a significant risk factor for this condition. Mono-2-ethylhexyl phthalate (MEHP), the toxic active metabolite of DEHP, has been proven to affect penile development and ultimately result in the hypospadias phenotype.